01852nas a2200217   4500008004100000245007500041210006900116300002200185490000700207520113000214653002101344653002001365653002001385653001601405653002301421100001901444700001701463700002401480700002001504856011001524       2021                        eng d00aBreathing in vitro: Designs and applications of engineered lung models0 aBreathing in vitro Designs and applications of engineered lung m  a204173142110086960 v123 a<p>The aim of this review is to provide a systematic design guideline to users, particularly engineers interested in developing and deploying lung models, and biologists seeking to identify a suitable platform for conducting in vitro experiments involving pulmonary cells or tissues. We first discuss the state of the art on lung in vitro models, describing the most simplistic and traditional ones. Then, we analyze in further detail the more complex dynamic engineered systems that either provide mechanical cues, or allow for more predictive exposure studies, or in some cases even both. This is followed by a dedicated section on microchips of the lung. Lastly, we present a critical discussion of the different characteristics of each type of system and the criteria which may help researchers select the most appropriate technology according to their specific requirements. Readers are encouraged to refer to the tables accompanying the different sections where comprehensive and quantitative information on the operating parameters and performance of the different systems reported in the literature is provided.</p>
10aaerosol exposure10afluidic systems10ain vitro models10aLung models10astretching systems1 aNossa, Roberta1 aCosta, Joana1 aCacopardo, Ludovica1 aAhluwalia, Arti  uhttp://615830.rige.asia/publications/breathing-vitro-designs-and-applications-engineered-lung-models.html